Everything the practice has published or made public lives here. Open questions we're sitting with, predictions before they're tested, structural reads of other people's data, essays about what we're learning, and papers when the work is ready.
Biology decides without anyone deciding. The same architecture — a capacitor loading to threshold, a factory building, a reactor meeting, a homeostat conserving — appears in a T cell, a falling leaf, a fly laying an egg. Read the cycle, and what the clinician is doing changes.
The Chen–Mellman cancer-immunity cycle has organised tumour immunology for thirteen years. Alongside its successes, clinical observations have accumulated that the cycle as drawn cannot resolve: PD-L1 predicts at AUC 0.63, response rates vary from 70% to 2% across cancer types with the same drug, cold tumours stay cold for reasons the cycle cannot name. This paper proposes that the seven Mellman steps are a true description of six of sixteen positions, and that the missing ten are where the unanswered questions live. Across 33 cancer types, only 4 stall at the synapse where anti-PD-1 acts.
Get in touch.