encounter

the model

Each cycle has sixteen positions, two axes, and zero, one, or more coupled peer cycles. Click any dot to descend into its sub-cycle. Click an axis to ascend into the axis-cycle. Click a peer to jump across. The framework's structure is recursive in every direction — no root, no bottom (canon §10).

domain: cellular biology › cycle_clonal_lineage_l5 ↓ hold-axis cycle_t_cell_l4
↑ cross-axis cycle_antigen_encounter_l3 novelty / change · click to ascend ← couples_to cycle_tumor_cellular_l4 3 channels · click to jump antigen IFN-γ cycle_t_cell_l4 T cell cycle · L4 · candidate P1 P2 P3 P4 P5 P6 P7 P8 P9 P10 P11 P12 P13 P14 P15 P16 POT CONSTRUCTION ENCOUNTER CONSERVATION positions with rings are clickable they have a cycle behind them ↓ hold-axis cycle_clonal_lineage_l5 parent / identity · click to ascend

P11 · Rejection-of-Rejection

SUB-ENCOUNTER OF ENCOUNTER · ENCOUNTER REGIME
Clinical meeting point: Sustained killing; sustained encounter under pressure. The cytolytic synapse.
Exhaust under pressure. The tumour cannot simultaneously maintain encounter AND build Conservation.
checkpoint inhibitors · BiTEs · CAR-T · adoptive transfer
Click to descend into P11's sub-cycle
↗ couples to cycle_tumor_cellular_l4 at P11 (granzyme)

cycle_t_cell_l4

T cell cycle · L4 · candidate
cross-axis
cycle_antigen_encounter_l3 · novelty input
hold-axis
cycle_clonal_lineage_l5 · identity-bearing parent
couples to
cycle_tumor_cellular_l4 · 3 channels
antigen P11→P1 · granzyme P11↔P11 · IFN-γ P11→P15
positions
P1-P4 P5-P8 P9-P12 P13-P16
interventions attached
16 (ipilimumab P4, CD40 P7, checkpoint inhibitors P9-P11, anti-CCR8 P15, ...)
failure modes
11 (P8 cDC1 licensing, P11 reactor low-rate, P15 Treg over-control, ...)
test result anchors
Chen-Mellman pan-cancer atlas · Soliman 2025 (HER2-DC1) · Ramamoorthi 2025

The graph, currently

v3.7 · commit 9496f2e · 2026-05-21
15
CYCLE NODES
9 populated · 6 templates
3
L-LEVELS POPULATED
L3, L4, L5 in cellular biology
15
COUPLING RULES
7 incoming · 5 outgoing · 2 temporal · 1 cycle-pair
47
CALIBRATION CASES
27 agree · 15 limit · 5 new-insight · 0 disagree
302
PASSING TESTS
across 52 invariants
1
PROSPECTIVE PREDICTION
Bertheau/Dry · awaiting trial readout
How navigation works. The cycle in the centre is the focal cycle. Sixteen positions sit on it (P1-P16), coloured by their outer regime. Above the cycle is its cross-axis — a smaller perpendicular ring representing the novelty input. Below is its hold-axis — a slightly wider parallel ring representing the parent identity context. To the sides are the peer cycles it couples to.

Click any element to navigate — but only what has a cycle behind it is clickable. Positions with a subtle outer ring (P1 and P11 here) have a coupled or sub-cycle modelled in the graph and can be clicked to navigate to that cycle. Plain dots have atlas content (sub_class, drugs, clinical meeting point) on hover but no destination — the framework asserts every position contains a cycle (canon §10), but if it hasn't been modelled yet, we don't fake the click. Axes are clickable when the axis-cycle is modelled. Peer cycle previews are clickable when a couples_to edge exists.

The framework's claim is that this recursion has no root and no bottom. Every cycle is reachable from any other in finitely many clicks if the structural relationships are encoded. What's in the graph today is a three-level slice through cellular biology (L3 → L4 → L5). The 6 templates (canonical L4, observer-below, etc.) are framework primitives, not domain-populated.